D-Lin-MC3-DMA-1
产品简称：D-Lin-MC3-DMA-1CAS no.：
厦门赛诺邦格专业提供D-Lin-MC3-DMA-1分子量642，提供1g-10kg多种规格，-20℃储存。工厂通过ISO9001/ISO13485认证，符合ICH-Q7A标准，同时支持定制合成服务。相关研究证实其在疫苗中的优异表现（Adv Mater. 2024）。
| CAS no. | 分子量（Mp） | 产品编码 |
| 642 | 06040008900 |
CDE登记号：F20220000342；DMF登记号：038644
相关文献：
1. Cheng X, Liu S, Sun J, et al. A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges. Adv Mater. 2024;36(13):e2310886. doi:10.1002/adma.202310886
2. Deng X, Yang Y, Gan L, et al. Engineering Lipid Nanoparticles to Enhance Intracellular Delivery of Transforming Growth Factor-Beta siRNA (siTGF-β1) via Inhalation for Improving Pulmonary Fibrosis Post-Bleomycin Challenge. Pharmaceutics. 2025;17(2):157. Published 2025 Jan 24. doi:10.3390/pharmaceutics17020157
3. Cheng X, Zheng X, Tao K, et al. Freezing induced incorporation of betaine in lipid nanoparticles enhances mRNA delivery. Nat Commun. 2025;16(1):4700. Published 2025 May 20. doi:10.1038/s41467-025-60040-9
4. Liu S, Wen Y, Shan X, et al. Charge-assisted stabilization of lipid nanoparticles enables inhaled mRNA delivery for mucosal vaccination. Nat Commun. 2024;15(1):9471. Published 2024 Nov 2. doi:10.1038/s41467-024-53914-x
5. Liu D, Wang X, Xu L, et al. Screening lipid nanoparticles using DNA barcoding and qPCR. Colloids Surf B Biointerfaces. 2025;251:114598. doi:10.1016/j.colsurfb.2025.114598
6. Mengyang Liu, Ruijuan Xing, et al. Branched ligand-functionalized immuno-evasive PEGylation (BLIP) platform: Breaking through accelerated blood clearance and chemoresistance barriers with dual-targeting RNAi-chemotherapy synergy, Chemical Engineering Journal, Volume 522, 2025, 167098, ISSN 1385-8947, https://doi.org/10.1016/j.cej.2025.167098.
7. Lv K, Yu Z, Wang J, et al. Discovery of Ketal-Ester Ionizable Lipid Nanoparticle with Reduced Hepatotoxicity, Enhanced Spleen Tropism for mRNA Vaccine Delivery. Adv Sci (Weinh). 2024;11(45):e2404684. doi:10.1002/advs.202404684
8. Maharjan R, Kim KH, Lee K, Han HK, Jeong SH. Machine learning-driven optimization of mRNA-lipid nanoparticle vaccine quality with XGBoost/Bayesian method and ensemble model approaches. J Pharm Anal. 2024;14(11):100996. doi:10.1016/j.jpha.2024.100996
9. Ren L, Zhao Z, Chao Y, et al. Optimization of Lipid Nanoparticles with Robust Efficiency for the Delivery of Protein Therapeutics to Augment Cancer Immunotherapy. Adv Sci (Weinh). 2025;12(17):e2500844. doi:10.1002/advs.202500844
10. Zong Y, Zhong H, Wang Y, Lin Y, Zhao L, Wang X, Cai J, Lin H, Xiao Y, Wei T, Guo S, Cheng Q. Safe and Highly Efficient Lipid-Pro-Dexamethasone Nanoparticles for mRNA Delivery and Base Editing. J Am Chem Soc. 2026 Mar 11;148(9):10225-10240. doi: 10.1021/jacs.6c01708. Epub 2026 Feb 24. PMID: 41733506.
11. Chen F, Ren S, Huang L, Wu Q, Li M, Li S, Gao J, Lai Y, Cai Z, Liu X, Tao W, Lammers T, Xu Z, Yu H. Ultrasound-Activatable Lipid Nanoplatform for Region-Confined Innate Immune Stimulation and mRNA Vaccination Therapy of Cancer. J Am Chem Soc. 2025 Nov 19;147(46):42221-42236. doi: 10.1021/jacs.5c06028. Epub 2025 Aug 25. PMID: 40854182.
关键词:新冠疫苗辅料D-Lin-MC3-DMA-1辉瑞疫苗PrizerModerna厦门赛诺邦格致力于药物释放系统工作，为全球的制药和医疗器械公司提供产品、技术与服务。我们的工厂通过了ISO9001和ISO13485认证，并按照ICH-Q7A（FDA原料药GMP指南）组织生产产品。
我们的网站可能没有完全列出所有产品，更多产品请致电：0592-7761068
我们同时向所有客户提供定制合成的服务，也可邮箱联系：sales@sinopeg.com
